The nearest airport is Perugia (Ryanair fly from Stansted): 1 hr 15 mins by car

Also within easy driving distance are:

Florence: 1 hr 45 mins

Rimini: 2 hrs

Pisa: 2 hrs 15 mins

Bologna: 2 hrs 30 mins

Rome: 2 hrs 45 mins

It is also really straightforward to come by train to Arezzo (30 mins away) and hire a car there.

The guys below are taking the vintage motorbike option - photographed during L’Intrepida vintage bike festival which takes place in Anghiari each October.